Effect of Starch Paste Preparation Temperature in Fluidized-Bed Granulation on Resultant Tablet Properties.
نویسندگان
چکیده
منابع مشابه
Granulation Time in Fluidized Bed Granulators
Size enlargement of fine powders by wet granulation involves mixing of fine particles with a binder liquid to form larger wet granules and drying them by evaporation of the binder liquid to form larger dry granules. Identification of the time for completion of granulation process is critical as further mixing of dry granules is providing extra energy for their attrition. In a batch fluidized be...
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Here, we statistically identified the critical factor of the granulation rate during the fluidized bed granulation process. Lactose was selected as the excipient and was granulated with several binders, including hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and polyvinylpyrrolidone. The viscosity, density, and surface tension of the binder solution, contact angle, and the work done ...
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The drying kinetics of hawthorn in a pilot-scale experimental fluidized bed dryer with and without vibration was investigated. The effect of operating parameters, such as vibration intensity, drying air flow rate, and temperature, on the drying rate and shrinkage of hawthorn was studied. The hawthorn fruit was dried at various drying air temperatures ranging from 40-70oC and drying air volume f...
متن کاملInvestigation of Physicochemical Drug Properties to Prepare Fine Globular Granules Composed of Only Drug Substance in Fluidized Bed Rotor Granulation.
The effect of some drug properties (wettability and particle size distribution) on granule properties (mean particle size, particle size distribution, sphericity, and granule strength) were investigated in a high (>97%) drug-loading formulation using fluidized bed rotor granulation. Three drugs: acetaminophen (APAP); ibuprofen (IBU); and ethenzamide (ETZ) were used as model drugs based on their...
متن کاملX-ray tomography of a fluidized bed Effect of pressure and fines on bubbles in a fluidized bed
Using a fast X-ray tomography setup measurements have been done on a 25 cm diameter f luidized bed of Geldart B pow^der and a 24 cm bed of Geldart A powder. The average bubble sizes have been determined over a measurement period of 60 seconds. The resolution of this setup is about 4.5 m m per pixel at a rate of 250 reconstructions per second. I t is possible to detect bubbles as small as 2.5 cm...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1995
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.43.473